<PAGE>   1
 

                                  SCHEDULE 14A
                                 (RULE 14A-101)
 
                    INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

          PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                     EXCHANGE ACT OF 1934 (AMENDMENT NO.  )
 
     Filed by the registrant [X]
 
     Filed by a party other than the registrant [ ]
 
     Check the appropriate box:
 
     [ ] Preliminary proxy statement.       [ ] Confidential, for use of the
                                                Commission only (as permitted by
                                                Rule 14a-6(e)(2).
 
     [X] Definitive proxy statement.
 
     [ ] Definitive additional materials.
 
     [ ] Soliciting material pursuant to Rule 14a-11(c) or Rule 14a-12.
 
                      Rockwell Medical Technologies, Inc.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)
 
--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement if Other Than the Registrant)
 
Payment of filing fee (check the appropriate box):
 
     [X] No fee required.
 
     [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
         0-11.
 
     (1) Title of each class of securities to which transaction applies:
 
--------------------------------------------------------------------------------
 
     (2) Aggregate number of securities to which transaction applies:
 
--------------------------------------------------------------------------------
 
     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
         filing fee is calculated and state how it was determined):
 
--------------------------------------------------------------------------------
 
     (4) Proposed maximum aggregate value of transaction:
 
--------------------------------------------------------------------------------
 
     (5) Total fee paid:
 
--------------------------------------------------------------------------------
 
     [ ] Fee paid previously with preliminary materials.
--------------------------------------------------------------------------------

     [ ] Check box if any part of the fee is offset as provided by Exchange Act
         Rule 0-11(a)(2) and identify the filing for which the offsetting fee
         was paid previously. Identify the previous filing by registration
         statement number, or the form or schedule and the date of its filing.
 
     (1) Amount Previously Paid:
 
--------------------------------------------------------------------------------
 
     (2) Form, Schedule or Registration Statement No.:
 
--------------------------------------------------------------------------------
 
     (3) Filing Party:
 
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     (4) Date Filed:
 
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<PAGE>   2
 
                      ROCKWELL MEDICAL TECHNOLOGIES, INC.
                               28025 OAKLAND OAKS
                             WIXOM, MICHIGAN 48393
 
Dear Shareholder:
 
     You are cordially invited to attend the Annual Meeting of Shareholders of
Rockwell Medical Technologies, Inc. (the "Company"), on Wednesday, May 17, 2000
at 9:00 a.m. at the Wyndham Garden Hotel, 42100 Crescent Boulevard, Novi,
Michigan. Your Board of Directors and management look forward to greeting
personally those Shareholders who are able to attend.
 
     The meeting principally concerns one matter of particular interest to the
Shareholders. One Director is to be elected for a three-year term expiring in
2003.
 
     Your Board of Directors supports this proposal and believes it is in the
best interests of the Company and of the Shareholders, and your Board of
Directors recommends a vote "FOR" the proposal. The accompanying Proxy Statement
contains additional information and should be reviewed carefully by
Shareholders. A copy of the Company's Annual Report for 1999 is also enclosed.
 
     It is important that your shares be represented and voted at the meeting,
whether or not you plan to attend. Please sign, date and mail the enclosed proxy
card at your earliest convenience.
 
     Your continued interest and participation in the affairs of the Company are
greatly appreciated.
 
                                          Sincerely,
 
                                          /s/ ROBERT L. CHIOINI
 
                                          Robert L. Chioini
                                          Chairman
 
Wixom, Michigan
April 10, 2000

<PAGE>   3
 
                      ROCKWELL MEDICAL TECHNOLOGIES, INC.
 

                 NOTICE OF 1999 ANNUAL MEETING OF SHAREHOLDERS
                                  MAY 17, 2000
                           -------------------------
 
To the Shareholders of Rockwell Medical Technologies, Inc.:
 
     Notice is hereby given that the 1999 Annual Meeting of Shareholders of
Rockwell Medical Technologies, Inc. (the "Company") will be held at the Wyndham
Garden Hotel, 42100 Crescent Boulevard, Novi, Michigan on May 17, 2000 at 9:00
a.m., to consider and take action upon the following matters:
 
          (1) The election of one (1) director for a term expiring in 2003; and
 
          (2) The transaction of such other business as may properly come before
     the meeting or any adjourning thereof.
 
     Only shareholders of record on April 6, 2000, will be entitled to notice
of, and to vote at, the meeting or any adjournment thereof.
 
     All Shareholders are cordially invited to attend the meeting. Whether or
not you intend to be present, please complete, date, sign and return the
enclosed proxy card in the stamped and addressed envelope enclosed for your
convenience. Shareholders can help the Company avoid unnecessary expense and
delay by promptly returning the enclosed proxy card. The business of the meeting
to be acted upon by the shareholders cannot be transacted unless at least a
majority of the outstanding Common Shares of the Company is represented at the
meeting.
 
     A copy of the Annual Report of the Company for the fiscal year ended
D
ecember 31, 1999, accompanies this Notice.
 
                                          By Order of the Board of Directors
 
                                          /s/ THOMAS E. KLEMA
 
                                          Thomas E. Klema
                                          Secretary

<PAGE>   4
 
                      ROCKWELL MEDICAL TECHNOLOGIES, INC.
                               28025 OAKLAND OAKS
                             WIXOM, MICHIGAN 48393
                           -------------------------
 
                                PROXY STATEMENT
                           -------------------------
 
                         ANNUAL MEETING OF SHAREHOLDERS
                                  MAY 17, 2000
                           -------------------------
 
                                  INTRODUCTION
 
GENERAL
 
     The Annual Meeting of Shareholders of Rockwell Medical Technologies, Inc.
(the "Company") will be held at the Wyndham Garden Hotel, 42100 Crescent
Boulevard, Novi, Michigan on Wednesday, May 17, 2000, at 9:00 a.m., Eastern
Daylight Time, for the purposes set forth in the accompanying Notice of Annual
Meeting of Shareholders. The approximate mailing date for this Proxy Statement
is April 12, 2000.
 
     It is important that your shares be represented at the meeting. Whether or
not you intend to attend the meeting, please sign and date the enclosed proxy
and return it to the Company. The proxy is solicited by the Board of Directors
of the Company. Common Shares represented by valid proxies in the enclosed form
will be voted if received in time for the Annual Meeting. The expenses in
connection with the solicitation of proxies will be borne by the Company and may
include requests by mail and personal contact by the Company's Directors,
officers and employees. The Company will reimburse brokers or other nominees for
their out-of-pocket expenses in forwarding proxy materials to principals. Any
person giving a proxy has the power to revoke it any time before it is voted.
 
     Gary D. Lewis, a Class II Director of the Company with a term expiring in
2002, and Norman L. McKee, a Class I Director of the Company with a term
expiring in 2001, resigned effective March 14, 2000. Subsequent to Mr. Lewis's
and Mr. McKee's resignation, the Board of Directors of the Company unanimously
elected Mr. Kenneth L. Holt as a Class II Director of the Company with a term
expiring in 2002 and Mr. Ronald D. Boyd as a Class I Director of the Company
with a term expiring in 2001.
 

VOTING SECURITIES AND PRINCIPAL HOLDERS
 
  Voting Rights and Outstanding Shares
 
     Only shareholders of record at the close of business on April 6, 2000 (the
"Record Date"), will be entitled to notice of, and to vote at, the Annual
Meeting or any adjournment of the meeting. As of the close of business on the
Record Date, the Company had 4,854,397 outstanding Common Shares, no par value
("Common Shares"), the only class of stock outstanding and entitled to vote.
 
     Each Common Share is entitled to one vote on each matter submitted for a
vote at the Annual Meeting. The presence, in person or by proxy, of the holders
of record of a majority of the outstanding Common Shares entitled to vote, or
2,427,199 Common Shares, is necessary to constitute a quorum for the transaction
of business at the meeting or any adjournment thereof.
 
 
 Revocability of Proxies
 
     A Shareholder giving a proxy may revoke it at any time before it is voted
by giving written notice of such revocation to the Secretary of the Company or
by executing and delivering to the Secretary a later dated proxy. Attendance at
the meeting by a Shareholder who has given a proxy will not have the effect of
revoking it unless such shareholder gives such written notice of revocation to
the Secretary before the proxy is voted.
 
                                        1

<PAGE>   5
 
Any written notice revoking a proxy, and any later dated proxy, should be sent
to Rockwell Medical Technologies, Inc., 28025 Oakland Oaks, Wixom, Michigan
48393, Attention: Thomas E. Klema, Secretary.
 
     Valid proxies in the enclosed form which are returned in time for the
Annual Meeting and executed and dated in accordance with the instructions on the
proxy will be voted as specified in the proxy. If no specification is made, the
proxies will be voted FOR the proposal described below.
 
  Principal Holders of the Company's Voting Securities
 
     The following table sets forth information with respect to persons known to
the Company to be the beneficial owners of more than five percent of the
outstanding Common Shares:
 

<TABLE>
<CAPTION>
                                                                                   PERCENT OF OUTSTANDING
                   NAME AND ADDRESS                        AMOUNT AND NATURE OF       COMMON SHARES AS
                  OF BENEFICIAL OWNER                      BENEFICIAL OWNERSHIP      OF RECORD DATE(A)
                  -------------------                      --------------------    ----------------------
<S>                                                        <C>                     <C>
Gary D. Lewis..........................................          603,400(b)                 12.4(b)
28025 Oakland Oaks
Wixom, Michigan 48393
Patricia Xirinachs.....................................          728,000(c)                 14.9(c)
28025 Oakland Oaks
Wixom, Michigan 48393
Robert L. Chioini......................................          657,500(d)                 13.1(d)
28025 Oakland Oaks
Wixom, Michigan 48393
</TABLE>

 
-------------------------
(a) Based on 4,854,397 Common Shares outstanding as of the Record Date.
 
(b) Includes 498,400 Common Shares owned jointly with Mr. Lewis's wife, 25,000
    Common Shares held in a custodial accounts for the benefit of Mr. Lewis's
    minor child and 50,000 Common Shares owned by two other children of Mr.
    Lewis, and includes 30,000 Common Shares that Mr. Lewis has the right to
    acquire within 60 days of the Record Date pursuant to the Company's 1997
    Stock Option Plan. This information is based solely on the Schedule 13-G
    filed by Mr. Lewis and his wife, a Form 4 filed by Mr. Lewis and his wife
    with the Securities and Exchange Commission on April 10, 2000 and
    conversations between the Company and the transfer agent.
 
(c) Includes 20,000 Common Shares that Mrs. Xirinachs' husband, Michael J.
    Xirinachs, has the right to acquire within 60 days of the Record Date
    pursuant to the Company's 1997 Stock Option Plan and 5,000 Shares which he
    owns. This information is based solely on the Schedule 13-G filed by Michael
    J. Xirinachs with the Securities and Exchange Commission on February 12,
    1999, Form 4s filed by Patricia Xirinachs in 1999, conversations between
    Michael J. Xirinachs and the Company and conversations between the Company
    and the transfer agent.
 
(d) Includes 157,500 Common Shares that Mr. Chioini has the right to acquire
    within 60 days of the Record Date pursuant to the Company's 1997 Stock
    Option Plan.
 
                            I. ELECTION OF DIRECTORS
 
     At the Annual Meeting, one Director comprising the Class III Directors is
to be elected for a three-year term expiring in 2003. It is intended that votes
will be cast pursuant to proxies received from Shareholders of the Company FOR
the nominee listed hereinafter, who is presently a Director of the Company,
unless contrary instructions are received.
 
     If for any reason the nominee becomes unavailable for election, the proxies
solicited will be voted for such nominee as is selected by management.
Management has no reason to believe that the nominee is not available or will
not serve if elected. The election of such Director will be decided by a
plurality of the Common Shares present and entitled to vote at the Annual
Meeting.
 
                                        2

<PAGE>   6
 
     The following Tables set forth the name, age, position with the Company,
principal occupation, term of service and beneficial ownership of Common Shares
with respect to the nominee for election as a Director, with respect to each
Director whose term of office as a Director will continue after this Annual
Meeting, and with respect to each executive officer of the Company named in the
Summary Compensation Table below.
 

<TABLE>
<CAPTION>
                                                               COMMON SHARES
                                                               OF THE COMPANY       PERCENTAGE OF
                                           POSITIONS AND        BENEFICIALLY     OUTSTANDING COMMON
         NAME AND YEAR                   OFFICES WITH THE       OWNED AS OF     SHARES OF THE COMPANY
         FIRST BECAME                    COMPANY AND OTHER       THE RECORD          OWNED AS OF        TERM AS DIRECTOR
          A DIRECTOR             AGE   PRINCIPAL OCCUPATIONS      DATE(A)        THE RECORD DATE(B)        TO EXPIRE
         -------------           ---   ---------------------   --------------   ---------------------   ----------------
<S>                              <C>   <C>                     <C>              <C>                     <C>
                                            NOMINEE FOR ELECTION AS DIRECTOR
Robert L. Chioini (1996).......  35    President and Chief         657,500(c)        13.1(c)                  2003
                                       Executive Officer of
                                       the Company
                                             DIRECTORS CONTINUING IN OFFICE
Kenneth L. Holt (2000).........  47    Co-owner of Savannah         40,500(d)              *                  2002
                                       Dialysis Specialists
                                       LLC
Ronald D. Boyd (2000)..........  37    Executive                     1,000                 *                  2001
                                       Vice-President
                                       Classic Medical, Inc.
                                                OTHER EXECUTIVE OFFICERS
Thomas E. Klema................  46    Vice President, Chief        44,083(e)              *
                                       Financial Officer,
                                       Treasurer and
                                       Secretary
All directors and all executive officers as a group
  (4 persons)...............................................       743,083(f)        14.7(f)
</TABLE>

 
-------------------------
 *  Less than 1%.
 
(a) All Directors and executive officers named herein have sole voting power and
    sole investment power with respect to Common Shares beneficially owned,
    except as otherwise noted below.
 
(b) Based on 4,854,397 Common Shares outstanding as of the Record Date.
 
(c) Includes 157,500 Common Shares that Mr. Chioini has the right to acquire
    within 60 days of the Record Date pursuant to the Company's 1997 Stock
    Option Plan.
 
(d) Includes 13,000 Common Shares that Mr. Holt has the right to acquire within
    60 days of the Record Date upon exercise of Common Share Purchase Warrants.
 
(e) Includes 42,083 Common Shares that Mr. Klema has the right to acquire within
    60 days of the Record Date pursuant to the Company's 1997 Stock Option Plan.
 
(f) Includes Common Shares which the directors and executive officers have the
    right to acquire within 60 days of the Record Date pursuant to the Company's
    1997 Stock Option Plan.
 
     ROBERT L. CHIOINI is a founder of the Company, has served as the Chairman
of the Board of the Company since March 2000, has served as the President and
Chief Executive Officer of the Company since February 1997 and has been a
Director of the Company since its formation in October 1996. From January 1996
to February 1997, Mr. Chioini served as Director of Operations of Rockwell
Medical Supplies, L.L.C., a company which manufactured hemodialysis concentrates
and distributed such concentrates and other hemodialysis products. From January
1995 to January 1996, Mr. Chioini served as President of Rockwell Medical, Inc.,
a company which manufactured hemodialysis kits and distributed such kits and
other hemodialysis products. From 1993 to 1995, Mr. Chioini served as a Regional
Sales Manager at Dial Medical of Florida, Inc. currently Gambro Healthcare, a
company which manufactures and distributes hemodialysis concentrates and owns
hemodialysis clinics. Mr. Chioini's employment agreement with the Company
expired February 19, 2000. Mr. Chioini is currently negotiating with the Board
of Directors for a new employment agreement.
 
                                        3

<PAGE>   7
 
     KENNETH L. HOLT was elected as a Director of the Company on March 14, 2000.
He is a founder and co-owner of Savannah Dialysis Specialists, LLC, a disease
management company specializing in the treatment of end-stage renal disease, and
has served as the Managing Partner since October of 1999. From 1996 to October
1999, Mr. Holt served as Vice President for Gambro Healthcare, Inc., in its
Carolinas Region, and held the same position at Vivra Renal Care, Inc., its
predecessor company, which was acquired in 1997 by Gambro Healthcare, Inc.
(Gambro Healthcare, Inc. is currently the second largest integrated dialysis
provider, manufacturer and distributor of renal care products in the United
States). From 1986 to 1996, Mr. Holt was also the founder, Co-owner and Managing
Partner in five dialysis clinics servicing approximately 350 dialysis patients.
 
     RONALD D. BOYD was elected as a Director of the Company on March 14, 2000.
He is a founder and Co-owner of Classic Medical, Inc., a dialysis and medical
products company, and has served as the Executive Vice President of Classic
Medical, Inc. since its inception in November of 1993. From May 1993 to November
1993, Mr. Boyd served as a consultant for Dial Medical of Florida, Inc., a
manufacturer and distributor of dialysis products. From 1990 to 1993, Mr. Boyd
served as a Regional Sales Manager for Future Tech, Inc., a dialysis products
distributor.
 
COMMITTEES OF THE BOARD OF DIRECTORS
 
     The Company has an Audit Committee which is presently comprised of Messrs.
Holt and Boyd. The Audit Committee's duties include the periodic review of the
Company's financial statements and meetings with the Company's independent
auditors. The Audit Committee's duties also include recommending to the Board of
Directors the conditions, compensation and term of appointment of the
independent certified public accountants for the audit of the Company's books
and accounts. During 1999, the Audit Committee held one meeting and had informal
discussions in lieu of additional meetings.
 
     The Company does not have a compensation committee or a nominating
committee.
 
     During the year ended December 31, 1999, the Board of Directors held three
meetings and took no action by written consent in lieu of a meeting. All of the
members of the Audit Committee of the Board of Directors attended the single
meeting of such committee.
 
                                        4

<PAGE>   8
 

                COMPENSATION OF EXECUTIVE OFFICERS AND DIRECTORS
 
  Summary Compensation Table
 
     The following table sets forth the compensation awarded to, earned by or
paid to the Company's Executive Officers for the years ended December 31, 1997,
1998 and 1999 awarded to, earned by or paid to Mr. Robert L. Chioini, the
Company's Chief Executive Officer, and the other executive officer of the
Company whose total annual salary and bonus exceeded $100,000 for the year ended
December 31, 1999. During the years ended December 31, 1997, 1998 and 1999, no
other officers earned in excess of $100,000 in total annual salary and bonus.
 
                           SUMMARY COMPENSATION TABLE
 

<TABLE>
<CAPTION>
                                                                                                LONG TERM
                                                                                               COMPENSATION
                                                                                                  AWARDS
                                                            ANNUAL COMPENSATION                ------------
                                                 ------------------------------------------     SECURITIES
                                                                               OTHER ANNUAL     UNDERLYING
     NAME AND PRINCIPAL POSITION         YEAR    SALARY($)        BONUS        COMPENSATION     OPTIONS(#)
     ---------------------------         ----    ---------        -----        ------------     ----------
<S>                                      <C>     <C>             <C>           <C>             <C>
Robert L. Chioini,...................    1999    $150,000(1)     $100,000(2)     $16,282(3)      160,000
  President and                          1998    $150,000(1)     $ 47,500(4)     $11,385(3)      100,000
  Chief Executive Officer                1997    $101,700(1)                     $46,828(5)       90,000
Thomas E. Klema,.....................    1999    $102,424(6)     $ 10,000(2)     $12,389(3)       85,000
  Vice President and Chief Financial
  Officer
</TABLE>

 
-------------------------
(1) On February 19, 1997, the Company entered into a three year employment
    agreement with Mr. Chioini pursuant to which Mr. Chioini is paid an annual
    salary of $150,000. Mr. Chioini is currently negotiating with the Board of
    Directors for a new employment agreement with the Company.
 
(2) 1999 Bonus represents incentive compensation related to 1999 paid or accrued
    in 1999.
 
(3) Other annual compensation includes executive perquisites for health, life
    and dental insurance and the Company's car allowance program.
 
(4) 1998 Bonus represents incentive compensation related to 1998 paid or accrued
    in 1998.
 
(5) Other annual compensation in 1997 included the amount of compensation
    ($32,812) attributable to the difference in exercise price of options to
    purchase Common Shares granted to Mr. Chioini and the initial public
    offering price of the Company's Common Shares of $4.00 per share, the
    Company's car allowance reimbursement program and executive perquisites for
    health, life and dental insurance.
 
(6) The Company and Mr. Klema entered into a two year employment agreement on
    January 12, 1999 to which Mr. Klema is paid an annual salary of $125,000.
 
                                        5

<PAGE>   9
 
  Option Grants and Related Information
 
     The following table provides information with respect to options granted
during fiscal year 1999 to the executive officers named in the Summary
Compensation Table above.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 

<TABLE>
<CAPTION>
                                                                         INDIVIDUAL GRANTS
                                                      -------------------------------------------------------
                                                      NUMBER OF      % OF TOTAL
                                                      SECURITIES      OPTIONS
                                                      UNDERLYING     GRANTED TO     EXERCISE OF
                                                       OPTIONS      EMPLOYEES IN    BASE PRICE     EXPIRATION
                       NAME                            GRANTED      FISCAL YEAR      ($/SHARE)        DATE
                       ----                           ----------    ------------    -----------    ----------
<S>                                                   <C>           <C>             <C>            <C>
Robert L. Chioini.................................     160,000(1)      64.0%            2.19        12/29/09
Thomas E. Klema...................................      35,000(1)      11.8%            2.19        12/29/09
Thomas E. Klema...................................      50,000(2)      16.9%            2.00        01/12/09
</TABLE>

 
-------------------------
(1) These options which were granted pursuant to the Company's 1997 Stock Option
    Plan, become exercisable annually in 25% increments beginning on the grant
    date (December 29, 1999) and have a term of ten years.
 
(2) These options which were granted pursuant to the Company's 1997 Stock Option
    Plan, become exercisable annually in one-third increments beginning on the
    grant date (January 12, 1999) and have a term of ten years.
 
                          AGGREGATED OPTION EXERCISES
                       AND FISCAL YEAR-END OPTION VALUES
 

<TABLE>
<CAPTION>
                                                                            NUMBER OF
                                                                      SECURITIES UNDERLYING    VALUE OF UNEXERCISED
                                                                       UNEXERCISED OPTIONS     IN-THE-MONEY OPTIONS
                                                                       AT FISCAL YEAR END       AT FISCAL YEAR END
                                       SHARES ACQUIRED     VALUE          (EXERCISABLE/           (EXERCISABLE/
               NAME                      ON EXERCISE      REALIZED       UNEXERCISABLE)           UNEXERCISABLE)
               ----                    ---------------    --------    ---------------------    --------------------
<S>                                    <C>                <C>         <C>                      <C>
Robert L. Chioini..................           0              0           157,500/192,500         $93,440/$145,920
Thomas E. Klema....................           0              0            25,416/ 59,584         $19,806/$ 45,354
</TABLE>

 
  Compensation of Directors
 
     The Company's Directors who are not officers or employees of the Company
(collectively, the "Outside Directors") receive $1,000 for each Board meeting
attended in person and $250 for each telephonic Board meeting attended. The
Company also reimburses Outside Directors for their reasonable expenses of
attending Board and Board committee meetings.
 
     In July 1997, the Board of Directors and shareholders of the Company
adopted the Rockwell Medical Technologies, Inc. 1997 Stock Option Plan (the
"Stock Option Plan"). The Stock Option Plan permits the Board of Directors,
among other things, to grant options to purchase Common Shares to Directors of
the Company, including Outside Directors. In July 1997, the Board of Directors
granted to each of the three existing Outside Directors options to purchase
20,000 Common Shares at a per share exercise price of $3.00. Upon the election
of any new member to the Board of Directors who is an Outside Director, the
Board of Directors intends to grant to such member an option to purchase 20,000
Common Shares at a per share exercise price equal to the fair market value of a
Common Share at the date of grant. Beginning with the first annual meeting of
the shareholders of the Company after July 1997, provided that a sufficient
number of Common Shares remain available under the Stock Option Plan, on each
date on which an annual meeting of the shareholders of the Company is held, the
Board of Directors intends to grant to each Outside Director who is then serving
on the Board of Directors, an option to purchase 5,000 Common Shares. The
exercise price of such options will be the fair market value of the Common
Shares on the date of grant. The options granted the
 
                                        6

<PAGE>   10
 
Outside Directors will generally become fully exercisable on the first
anniversary of the date of grant. Such options will expire ten years after the
date of grant. If an Outside Director becomes an officer or employee of the
Company and continues to serve as a member of the Board of Directors, options
granted under the Stock Option Plan will remain exercisable in full.
Notwithstanding the foregoing, the Company did not grant such options to Outside
Directors in 1998. In December, 1999 the Board of Directors granted each of the
Outside Directors an option to purchase 20,000 Common Shares at a per share
exercise price of $2.188, the fair market value of a Common Share on such date.
These options vest in two equal annual installments beginning on the grant date.
 
  Employment Agreements
 
     The Company entered into an employment agreement with Robert L. Chioini in
February 1997, pursuant to which Mr. Chioini was employed as the President and
Chief Executive Officer of the Company for a period ending February 19, 2000.
Under the agreement, Mr. Chioini's base salary was set at $115,000, which may be
increased by the Board of Directors. At the closing of the Company's initial
public offering, the Board increased Mr. Chioini's base salary to $150,000. Mr.
Chioini's employment agreement contains a three year non-compete provision and
provides that he devote his full-time and attention to the Company's business.
Mr. Chioini is currently negotiating with the Board of Directors on the terms of
a new Employment Agreement with the Company.
 
     The Company entered into an employment agreement with Thomas E. Klema,
effective as of January 12, 1999, pursuant to which Mr. Klema is employed as
Vice President of Finance, Chief Financial Officer, Treasurer and Secretary of
the Company for a period ending January 12, 2001. Mr. Klema's base salary is
$125,000, which may be increased by the Board of Directors. In addition,
pursuant to his employment agreement, (1) Mr. Klema was granted the option to
purchase 50,000 shares of the Company's Common Shares, vesting in three equal
annual installments beginning on January 12, 1999, exercisable at a price per
share equal to the average high and low selling price of the Company's Common
Shares on each such grant date and (2) Mr. Klema receives a monthly car
allowance of $480 (plus reimbursement for fuel and routine maintenance costs).
Mr. Klema's employment agreement contains a one year non-compete provision and
provides that he devote his full time and attention to the Company's business.
 
C
OMPLIANCE WITH SECTION 16(a) OF THE SECURITIES EXCHANGE ACT OF 1934
 
     Section 16(a) of the Securities Exchange Act of 1934, as amended ("Exchange
Act"), requires the Company's officers and Directors and persons who own more
than ten percent of a registered class of the Company's equity securities to
file reports of ownership and changes in ownership with the Securities and
Exchange Commission (the "Commission") and the Nasdaq Stock Market. Officers,
Directors and greater than ten percent Shareholders are required by regulation
of the Commission to furnish the Company with copies of all Section 16(a) forms
they file.
 
     Based solely on its review of the copies of such forms received by it, or
written representation from certain reporting persons that no Forms 5 were
required for those persons, the Company believes that, during the Company's
current fiscal year ended December 31, 1999, Thomas E. Klema, a Vice President
and the Chief Financial Officer of the Company, filed his Form 3 late. Robert L.
Chioini, the President of the Company, filed his Form 5 late reflecting one
transaction. Norman L. McKee, a former Director of the Company, filed his Form 5
late reflecting one transaction. Catherine G. Lewis, the spouse of Gary D.
Lewis, a former Director and a 10% Shareholder, filed her Form 3 and three Form
4s late to report her joint holdings with her husband. Her Form 4s reflected
nine transactions. Patricia Xirinachs, a 10% shareholder of the Company, did not
file a Form 5.
 
                                        7

<PAGE>   11
 
T
RANSACTIONS WITH MANAGEMENT
 
  Acquisition of Business of Predecessor Company
 
     On February 19, 1997, the Company acquired the business of Rockwell Medical
Supplies, L.L.C. (the "Supply Company") and Rockwell Transportation, L.L.C. (the
"Transportation Company" and together with the Supply Company, the "Predecessor
Company") for total consideration of $2,441,664.47 pursuant to an Asset Purchase
Agreement dated as of November 1, 1996, as amended (the "Asset Purchase
Agreement"). Mr. Robert L. Chioini, the President, Chief Executive Officer and a
Director of the Company, owned a 20% equity interest in the Supply Company. The
purchase price consisted of (i) $150,000 paid to the Sellers in cash; (ii) a
cash payment to NBD Bank of approximately $375,000 to retire an outstanding debt
owed by the Predecessor Company to NBD Bank; and (iii) an 8.5% promissory note
in the principal amount of $1,916,664.47 made by the Company in favor of the
Supply Company (the "Note"). In addition, in connection with the purchase of the
business from the Predecessor Company, the Company paid $178,000 to the landlord
under the lease pursuant to which the Company leases its manufacturing facility
as a prepayment of future rents and as an additional security deposit in order
to induce such landlord to consent to the assignment of the lease and to release
the Predecessor Company and its shareholders, including Mr. Chioini, from their
obligations under such lease.
 
     Under the terms of the Note and the Asset Purchase Agreement, a prepayment
of $500,000 on the Note was due on May 19, 1997, which date was extended by the
Supply Company to May 31, 1997. Pursuant to a letter agreement dated April 4,
1997, the Supply Company agreed that, upon receipt of the $500,000 prepayment on
the Note, the remaining principal balance under the Note would be converted into
shares of Series A Preferred Stock at a conversion ratio of one share of Series
A Preferred Stock for each $1.00 of outstanding principal due under the Note.
The Company made the required $500,000 prepayment under the Note and the Note
was converted into 1,416,664 shares of Series A Preferred Stock.
 
     In accordance with the terms of the Asset Purchase Agreement, the purchase
price paid by the Company for the Predecessor Company's business was reduced by
$320,749 based on a provision in the Asset Purchase Agreement which provides
that the purchase price would be reduced on a dollar for dollar basis to the
extent that the net worth of the Predecessor Company at the closing of the
acquisition was below a target amount set forth in the Asset Purchase Agreement.
320,749 shares of Series A Preferred Stock were surrendered by the Supply
Company to the Company for cancellation in payment of such purchase price
adjustment. In accordance with the terms of the Series A Preferred Stock, the
Company redeemed the remaining 1,095,915 shares of Series A Preferred Stock on
January 30, 1998 for an aggregate redemption price of $1,158,187.
 
 
 Consulting Agreement
 
     The Company was party to consulting agreement with Wall Street Partners,
Inc. ("Wall Street") dated as of February 19, 1997 pursuant to which Wall Street
provided management and financial consulting services to the Company. The
Company agreed to pay Wall Street a consulting fee of $25,000 per month from the
date of the agreement through June 30, 1998, subject to renewal upon the mutual
agreement of the Company and Wall Street. Such agreement was renewed through
October 31, 1998. The Company also renewed the Agreement with Wall Street from
November 1, 1998 to December 31, 1998, but for a reduced fee of $20,000 per
month. In addition, the Company and Wall Street renewed such agreement (at a fee
of $20,000 per month), from January 1, 1999 to March 31, 1999, from April 1,
1999 through June 30, 1999, and from July 1, 1999 through December 31, 1999. On
December 31, 1999 the term of the consulting agreement, as extended, expired and
the Company chose not to renew the consulting agreement. Prior to February 19,
1997, Wall Street rendered consulting services to the Company beginning in
November 1996 for a consulting fee of $25,000 per month. Wall Street is owned by
Gary D. Lewis and, until October, 1998, by Michael J. Xirinachs, each of whom is
a founder of the Company. The Company has paid Wall Street an aggregate of
$290,000 during the Company's fiscal year ended December 31, 1998 and $240,000
during the Company's fiscal year ended December 31, 1999.
 
                                        8

<PAGE>   12
 
                                 OTHER MATTERS
 
ANNUAL REPORT
 
     A copy of the Annual Report to Shareholders for the fiscal year ended
December 31, 1999 accompanies this Proxy Statement. The Company files an Annual
Report on Form 10-KSB with the Securities and Exchange Commission. The Company
will provide, without charge, to each person being solicited by this Proxy
Statement, upon the written request of any such person, a copy of the Company's
Annual Report on Form 10-KSB for the fiscal year ended December 31, 1999 (as
filed with the Securities and Exchange Commission, excluding exhibits for which
a reasonable charge shall be imposed). If a person requesting the Annual Report
was not a shareholder of record on April 6, 2000, the request must contain a
good faith representation that the person making the request was a beneficial
owner of Common Shares at the close of business on such date. All such requests
should be directed to Thomas E. Klema, Chief Financial Officer and Secretary,
Rockwell Medical Technologies, Inc., 28025 Oakland Oaks, Wixom, Michigan 48393.
 
CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANTS.
 
     On November 25, 1998, the Company and PricewaterhouseCoopers LLP, the
Company's independent accountants, agreed to cease their client-auditor
relationship. In connection with its audit for fiscal year 1997, and during the
interim period preceding such mutually-agreed cessation, there were no
disagreements between the Company and PricewaterhouseCoopers LLP on any matter
of accounting principles or practices, financial statement disclosure, or
auditing scope or procedure, which disagreements, if not resolved to the
satisfaction of PricewaterhouseCoopers LLP, would have caused them to make
reference thereto in their report on the financial statements.
PricewaterhouseCoopers LLP's report with respect to the Company's financial
statements for 1997 contained no adverse opinion or disclaimer of opinion and
was not qualified or modified as to audit scope or accounting principles;
however, such report was modified as to uncertainty regarding the Company's
ability to continue as a going concern.
 
     On December 24, 1998, the Company appointed the accounting firm of Plante &
Moran, LLP, independent public accountants, to audit and report upon the
financial statements of the Company for the year ended December 31, 1998. This
appointment of independent accountants was approved by the audit committee of
the Board of Directors of the Company. There were no consultations with Plante &
Moran, LLP, regarding the application of accounting principles to specific
transactions, or the type of audit opinion that might be rendered.
 
RELATIONSHIP WITH INDEPENDENT AUDITOR
 
     Plante & Moran, LLP is the independent auditor for the Company and its
subsidiaries and has reported on the Company's consolidated financial statements
included in the Annual Report of the Company which accompanies this proxy
statement. The Company's independent auditor is appointed by the Board of
Directors. The Board of Directors has reappointed Plante & Moran, L.L.P. as
independent auditor for the year ending December 31, 2000.
 
     Representatives of Plante & Moran, LLP are expected to be present at the
Annual Meeting of the Shareholders and will have the opportunity to make a
statement at the meeting if they desire to do so. The representatives will also
be available to respond to appropriate questions.
 
SHAREHOLDER PROPOSALS
 
     A shareholder proposal which is intended to be presented at the Company's
2001 Annual Meeting of Shareholders must be received by the Company's Secretary
at the Company's principal executive office, 28025 Oakland Oaks, Wixom, Michigan
48393, by December 15, 2000 to be considered for inclusion in the Proxy
Statement and Proxy relating to that meeting. Such proposal should be sent by
certified mail, return receipt requested.
 
     The Company must receive notice of any proposals of shareholders that are
intended to be presented at the Company's 2001 Annual Meeting of Shareholders,
but that are not intended to be considered for inclusion
                                        9

<PAGE>   13
 
in the Company's Proxy Statement and Proxy related to that meeting, no later
than February 26, 2001 to be considered timely. Such proposals should be sent by
certified mail, return receipt requested and addressed to the Company's
Secretary at the Company's principal executive office, 28025 Oakland Oaks,
Wixom, Michigan 48393. If the Company does not have notice of the matter by that
date, the Company's form of proxy in connection with that meeting may confer
discretionary authority to vote on that matter, and the persons named in the
Company's form of proxy will vote the shares represented by such proxies in
accordance with their best judgment.
 
OTHER BUSINESS
 
     Neither the Company nor the members of its Board of Directors intend to
bring before the Annual Meeting any matters other than those set forth in the
Notice of Annual Meeting of Shareholders, and they have no present knowledge
that any other matters will be presented for action at the meeting by others. If
any other matters properly come before such meeting, however, it is the
intention of the persons named in the enclosed form of proxy to vote in
accordance with their best judgment.
 
                                          By Order of the Board of Directors
 
                                          /s/ THOMAS E. KLEMA
 
                                          Thomas E. Klema
                                          Secretary
 
Wixom, Michigan
April 10, 2000
 
                                       10

<PAGE>   14




                                                ________________________________
                                                WHEN PROXY IS OKAYED PLEASE SIGN
                                                        & DATE IT ABOVE




                        Please date, sign and mail your

                      proxy card back as soon as possible!



                         Annual Meeting of Shareholders

                      ROCKWELL MEDICAL TECHNOLOGIES, INC.









<TABLE>
<S><C>
                                      \/ Please Detach and Mail in the Envelope Provided \/
------------------------------------------------------------------------------------------------------------------------------------
      PLEASE MARK YOUR                                                                                            |
A [X] VOTES AS IN THIS                                                                                            |    
      EXAMPLE.                                                                                                    |_____


                  FOR  WITHHELD   
1. Election of a  [ ]    [ ]    NOMINEE: Robert L. Chioini  2. In their discretion with respect to any other matters that may 
   Class III                                                   properly come before the meeting.   
   Director    
     
                                                            THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED IN ACCORDANCE WITH
                                                            THE SPECIFICATIONS MADE HEREIN. THE SHARES REPRESENTED BY THIS PROXY
                                                            WILL BE VOTED FOR THE ELECTION OF THE ONE NOMINEE IF NO INSTRUCTIONS TO 
                                                            THE CONTRARY ARE INDICATED OR IF NO INSTRUCTION IS GIVEN.

                                                            PLEASE DATE, SIGN AND RETURN THIS PROXY PROMPTLY IN THE ENCLOSED 
                                                            ENVELOPE.









SIGNATURE(S)_______________________________ DATE___________, 2000   SIGNATURE(S)______________________________ DATE__________, 2000

NOTE: (PLEASE SIGN EXACTLY AS NAME APPEARS HEREON. EXECUTORS, ADMINISTRATORS, ATTORNEYS, GUARDIANS, TRUSTEES, ETC. SHOULD SO
INDICATE WHEN SIGNING, GIVING FULL TITLE AS SUCH. IF SIGNER IS A CORPORATION, EXECUTE IN FULL CORPORATE NAME BY AUTHORIZED OFFICER.
IF SHARES ARE HELD IN THE NAME OF TWO OR MORE PERSONS, ALL SHOULD SIGN.)

------------------------------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>   15



                                                --------------------------------
                                                WHEN PROXY IS OKAYED PLEASE SIGN
                                                         & DATE IT ABOVE










--------------------------------------------------------------------------------

                      ROCKWELL MEDICAL TECHNOLOGIES, INC.
          BOARD OF DIRECTORS PROXY FOR THE ANNUAL MEETING MAY 17, 2000
         THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS OF
                      ROCKWELL MEDICAL TECHNOLOGIES, INC.

     The undersigned hereby appoints Robert L. Chioini and Thomas E. Klema, and
each of them, attorneys and proxies with full power of substitution in each of
them, in the name, place and stead of the undersigned to vote as proxy all the
Common Shares, no par value per share, of the undersigned in Rockwell Medical
Technologies, Inc. (the "Company") which the undersigned is entitled to vote at
the Annual Meeting of Shareholders of the Company to be held on May 17, 2000,
and at any and all adjournments thereof.
                                                                    -----------
                                                                    SEE REVERSE
                        (TO BE SIGNED ON REVERSE SIDE)                  SIDE
                                                                    -----------

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