United States securities and exchange commission logo

                          October 5, 2021

       Russell Skibsted
       Chief Financial Officer
       Rockwell Medical, Inc.
       30142 S. Wixom Road
       Wixom, Michigan 48393

                                                        Re: Rockwell Medical,
                                                            CIK 0001041024
                                                            S-3 filed September
30, 2021
                                                            File No. 333-259923

       Dear Mr. Skibsted:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Daniel
Crawford at 202-551-7767 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences