Rockwell Medical Reports Second Quarter Sales Increase of 15.5%;Margins Increase Sequentially

Rockwell Medical Reports Second Quarter Sales Increase of 15.5%; Margins Increase Sequentially

• Quarterly revenue of $12.2 million increased 15.5% or $1.6 million compared to 2007.
• Domestic sales were up 16.4% compared to the second quarter of 2007
• Sequential domestic revenue increased 5.5% in the second quarter over the first quarter although total sales were 1.9% lower due to lower international orders compared to the first quarter.
• Gross profit margins rose sequentially 2.1 percentage points to 9.0% compared to the first quarter but were down 1.6 percentage points compared to the second quarter of 2007.
• SG&A expense included non-cash charges for stock options and warrants of $.3 million.
• SFP related R&D spending of $.8 million was 6.4% of sales.
• Loss of ($1.1 million) compared to a loss of ($.5 million) in the second quarter 2007.
• Cash position at June 30, 2008 was $9.7 million.

• Sales increased 22.8% or $4.6 million to $24.6 million in the first half of 2008 vs. 2007
• Domestic sales increased 19.1% while international sales were up 94% compared to the first half of 2007.
• Gross Profit margins increased 2.8% to 7.9% compared to the first half of 2007.
• SG&A expense included non-cash charges for stock options and warrants of $.7 million.
• R&D expense was $1.6 million in the first half of 2008 and in the first half of 2007.
• Loss of ($2.3 million) compared to a loss of ($2.1 million) in the first half of 2007.

• Added significant expertise to the Company's Scientific Advisory Board with the appointment of three additional renal failure and iron experts in the renal field.
• Modified SFP Phase II-b Dose Ranging Study protocol to reflect changes to industry hemoglobin standards.
• Modified SFP Phase II-b Dose Ranging Study protocol to accelerate enrollment and study completion.
• Commenced enrollment for a 9-month National Institutes of Health (NIH) funded SFP study.
• Commenced recruitment for a Chief Medical Officer.

Mr. Robert L. Chioini, Chairman and CEO stated, "Our SFP clinical development program continues to progress and we are confident that we have taken necessary actions to complete the trial as effectively as possible. We have increased the resources devoted to development and revised the protocol to facilitate enrollment wherever practical. We look forward to advancing the SFP study and expanding our senior management team as we begin to distinguish ourselves within the specialty pharma market. Overall, second quarter results were in line with our expectations."

Rockwell will be hosting a conference call to review its second quarter results and to provide investors with an update on its business development efforts on Tuesday, August 12, 2008 at 11:00 am eastern time.

Investors are encouraged to call in several minutes in advance at (877) 440-5803 to hear the call or they may listen on the web at the following link:
http://investor.shareholder.com/media/eventdetail.cfm?mediaid=32850&c=RMTI&mediakey=803E36B7FDC0F7E12EBCE5CA76E150CB&e=0

See www.rockwellmed.com for more details and playback options.

Rockwell is a leading, innovative manufacturer and developer of renal drug therapies and critical products focused on improving the quality of care for dialysis patients. Dialysis is a process that duplicates kidney function for those patients who suffer from chronic kidney failure, a condition also known as end-stage-renal-disease (ESRD). There are an estimated 370,000 ESRD patients in the United States growing approximately 3-5% on average each year and approximately 2 million ESRD patients world-wide. Rockwell's products are used to maintain life, removing toxins and replacing necessary nutrients in the dialysis patient's bloodstream. Rockwell is currently developing unique, proprietary renal drug therapies for iron maintenance utilizing its dialysate as the delivery mechanism. These exclusive renal drug therapies support disease management initiatives to improve the quality of life and care of dialysis patients and are designed to deliver safe and effective therapy while decreasing cost.

Certain statements in this press release constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. When we use words such as "may," "might," "will," "should," "believe," "expect," "anticipate," "estimate," "continue," "predict," "forecast," "projected," "intend" or similar expressions, or make statements regarding our anticipated future financial condition, operating results, cash flows or business plans, we are making forward-looking statements. While we believe these forward-looking statements are reasonable, you should not place undue reliance on any such forward-looking statements which are based on information available to us on the date of this release. Because these forward looking statements are based upon estimates and assumptions that are subject to significant business, economic and competitive uncertainties, many of which are beyond our control or are subject to change, actual results could be materially different. Factors which could cause such a difference include, without limitation, the risk factors and other risks and uncertainties set forth in the Company's SEC filings, including its Form 10-K for the year ended December 31, 2007 and its Forms 10-Q filed during 2008. The forward-looking statements should be considered in light of these risks and uncertainties. We do not undertake, and expressly disclaim any obligation, to update or alter our statements whether as a result of new information, future events or otherwise, except as required by law.